To provide best website performance it makes sense to minify static HTML files. There several ways to do that. One of the most easiest is to use django-htmlmin. To install run:
python-pip install django-htmlmin
To minify run:
pyminify index.html > index_minified.html
It would make sense to tar/zip files before you minify them.
You can also use it as a library for Flask and, obviously, Django. Check the documentation to get the details.